European journal of internal medicine
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Eur. J. Intern. Med. · Dec 2021
A metabolomic index based on lipoprotein subfractions and branched chain amino acids is associated with incident hypertension.
The present study aims to evaluate the performance of the Diabetes Risk Index (DRI), a metabolomic index based on lipoprotein particles and branched chain amino acids, on the incidence of newly developed hypertension in a large community dwelling cohort. ⋯ Higher DRI scores were associated with an increased risk of incident hypertension. Such association was independent of traditional clinical risk factors for hypertension.
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Eur. J. Intern. Med. · Dec 2021
Diagnostic yield of endoscopy in irritable bowel syndrome: A nationwide prevalence study 1987-2016.
Symptoms of irritable bowel syndrome (IBS) are common reasons for endoscopic procedures. We examined the yield of colonoscopy and upper endoscopy in IBS for several organic diseases. ⋯ The diagnostic yield of upper endoscopy and colonoscopy for organic disease is low in patients with a first-time diagnosis of IBS, though increases with age.
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Eur. J. Intern. Med. · Dec 2021
Outcomes of patients with heart failure with preserved ejection fraction discharged on treatment with neurohormonal antagonists after an episode of decompensation.
To analyze the frequency with which patients with heart failure with preserved ejection fraction (HFpEF) discharged after an acute heart failure (AHF) episode are treated with antineurohormonal drugs (ANHD), the variables related to ANHD prescription and their relationship with outcomes. ⋯ 70% of HFpEF patients are discharged with ANHD after an AHF episode. ANHD do not seem to reduce mortality or adverse events in HFpEF patients, only RAASi could provide some benefits, reducing the risk of hospitalization for AHF.
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Doctors are often asked to make input into bed calculations but are often not provided with the necessary background to the potential flaws in such calculations. A simple method is presented which allows both inter- and intra-national comparison of bed numbers which are sensitive to both population age structure and the role of nearness-to-death in medical bed demand. Local adjustment will be required to account for the additional demand arising for hospitals servicing more deprived populations.