European journal of internal medicine
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Eur. J. Intern. Med. · Aug 2022
High risk of complications and acute-on-chronic liver failure in cirrhosis patients with acute pancreatitis.
Acute pancreatitis (AP) is a frequent indication for hospitalization and may present with varying degrees of severity. AP often coincides with hepatic disease, yet the impact of liver cirrhosis (LC) on the course of AP is uncertain, and early identification of patients at risk for complications remains challenging. We aimed to assess the impact of LC on the development of pancreatic and extra-pancreatic complications of AP, and to identify predictors of adverse outcomes in cirrhotic patients. ⋯ Among AP patients, concomitant cirrhosis substantially increases the risk for infections, periprocedural complications, multiorgan failure and death.
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Eur. J. Intern. Med. · Aug 2022
External validation of risk scores to predict in-hospital mortality in patients hospitalized due to coronavirus disease 2019.
The coronavirus disease 2019 (COVID-19) presents an urgent threat to global health. Prediction models that accurately estimate mortality risk in hospitalized patients could assist medical staff in treatment and allocating limited resources. ⋯ Although performances did not differ greatly, the 4C mortality score showed the best performance. However, because of quickly changing circumstances, model recalibration may be necessary before using the 4C mortality score.
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Eur. J. Intern. Med. · Aug 2022
T-cell immune response predicts the risk of critical SARS-Cov2 infection in hospitalized COVID-19 patients.
This study aimed to identify markers of disease worsening in patients hospitalized for SARS-Cov2 infection. ⋯ This study suggests that an elevated percentage of Th17 cells in patients hospitalized for SARS-Cov2 infection is associated with an increased risk of progression to critical disease. If these data are confirmed in a larger study, this marker could be used to better target the population of patients in whom tocilizumab could decrease the risk of progression to critical COVID-19.
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Eur. J. Intern. Med. · Aug 2022
Atrial cardiomyopathy markers and new-onset atrial fibrillation risk in patients with acute myocardial infarction.
New-onset atrial fibrillation (NOAF) after acute myocardial infarction (AMI) is common and independently correlated with poor prognosis. The purpose of this study is to explore whether atrial cardiomyopathy (ACM) markers improve NOAF risk assessment and contribute to therapy decision-making to improve prognosis. ⋯ Atrial cardiomyopathy markers including PTFV1, LAD, and BNP were strongly associated with NOAF after AMI. The prediction performance of the clinical model for NOAF was increased by the addition of these markers.
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Eur. J. Intern. Med. · Aug 2022
Impact of cardiac amyloidosis on outcomes of patients hospitalized with heart failure.
Amyloidosis is a multi-systemic disease potentially leading to failure of affected organs. We aimed to investigate prevalence and prognostic implications of cardiac amyloidosis of any etiology on outcomes of hospitalized patients with heart failure (HF) in Germany. ⋯ CA was identified as an independent risk factor for complications and in-hospital mortality in HF patients, whereby it has to be mentioned that amyloidosis subtypes could not differentiated in the present study. Physicians should be aware of this issue concerning treatments and monitoring of CA-patients.