European journal of internal medicine
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Eur. J. Intern. Med. · Nov 2003
Acute, painful, and swollen testicle as the presenting feature in polyarteritis nodosa.
A 74-year-old man presented with spiking fever, myalgias, and a painful left testicle. A diagnosis of polyarteritis nodosa (PAN) was made. Corticosteroids, in combination with cyclophosphamide, induced clinical remission.
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Eur. J. Intern. Med. · May 2003
Interrelationship of smoking, paraoxonase activity, and leisure time physical activity: a population-based study.
We determined the effect of smoking on PON1 activity levels in a population-based sample of 1380 subjects and examined the possibility of regular physical activity modulating the effect of cigarette smoking on PON1 activity levels at a population level. ⋯ Smoking appears to have a deleterious effect on PON1 activity levels. Being physically active clearly attenuates this effect.
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Eur. J. Intern. Med. · Dec 2002
Clinical practice of nutritional support in Dutch intensive care units: a survey.
A questionnaire was sent to all Dutch ICUs. The design of the study was a 1-day point prevalence study. ⋯ Nutritional support is provided to the majority of critically ill patients. Enteral feeding is more common than parenteral nutrition.
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Eur. J. Intern. Med. · Aug 2002
Autoantibodies and defined target autoantigens in autoimmune hepatitis: an overview.
Autoimmune hepatitis (AIH) is a disease of unknown aetiology characterised by hypergammaglobulinaemia, non-organ and liver-related autoantibodies, association with HLA-DR3 or DR4 and a favourable response to immunosuppression. The current classification of AIH and the several autoantibodies/target autoantigens found in this disease are reported. The importance of these markers in the differential diagnosis and the study of pathogenesis of AIH is also given. ⋯ Autoantibodies against liver microsomes (anti-LM) are the specific autoantibodies found in AIH as a disease component of APS-1. However, anti-LM autoantibodies have also been described in cases of dihydralazine-induced hepatitis. Cytochrome P450 1A2 has been identified as the target autoantigen of anti-LM autoantibodies in both disease entities.