International psychogeriatrics
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Randomized Controlled Trial Comparative Study
Donepezil for negative signs in elderly patients with schizophrenia: an add-on, double-blind, crossover, placebo-controlled study.
Cognitive impairment and negative signs are common in patients with schizophrenia. Up to 35% of elderly patients with schizophrenia fulfill the diagnostic criteria of dementia. Donepezil inhibits cholinesterase, thus enhancing cholinergic neurotransmission. We tested the efficacy of donepezil in elderly patients with chronic schizophrenia and severe cognitive impairment. ⋯ Donepezil does not seem to improve negative signs and cognitive impairment in elderly patients with chronic schizophrenia.
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Randomized Controlled Trial Clinical Trial
Patient populations in clinical studies of donepezil in vascular dementia.
There are difficulties in accurately defining patients with vascular dementia (VaD) and, therefore, little is known about the characteristics of this population. ⋯ The patients enrolled in these trials had probable or possible VaD; these patients exhibited a history of cerebrovascular disease and a broad range of comorbid cardiovascular conditions. The large number of patients enrolled will permit a thorough examination of the efficacy and tolerability of donepezil in VaD.
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Randomized Controlled Trial Clinical Trial
Psychosocial intervention for dementia caregivers: what can it accomplish?
Research has shown that psychosocial intervention can have a significant benefit for patients and caregivers. Randomized controlled trials of psychosocial intervention for spouse-caregivers can improve social support and reduce depression among the caregivers and help prevent or postpone nursing home placement of their spouses with Alzheimer's disease.
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Case Reports Randomized Controlled Trial Comparative Study Clinical Trial
Effects of individualized versus classical "relaxation" music on the frequency of agitation in elderly persons with Alzheimer's disease and related disorders.
Confusion and agitation in elderly patients are crucial problems. This study tested Gerdner's mid-range theory of individualized music intervention for agitation. An experimental repeated measures pretest-posttest crossover design compared the immediate and residual effects of individualized music to classical "relaxation" music relative to baseline on the frequency of agitated behaviors in elderly persons with Alzheimer's disease and related disorders (ADRD). ⋯ The Modified Cohen-Mansfield Agitation Inventory measured the dependent variable. A repeated measures analysis of variance with Bonferroni post hoc test showed a significant reduction in agitation during and following individualized music compared to classical music. This study expands science by testing and supporting a theoretically based intervention for agitation in persons with ADRD.