The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
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J. Heart Lung Transplant. · Nov 2015
Multicenter StudyImpact of lung allocation score on survival in cystic fibrosis lung transplant recipients.
The lung allocation score (LAS) has changed organ allocation for lung transplantation in the United States. Previous investigations of transplant recipients reported an association between high LAS and an increased risk of death after lung transplantation. We hypothesize that a high LAS predicts survival in lung transplant recipients with cystic fibrosis (CF) in the United Network for Organ Sharing Scientific Registry of Transplant Recipients database. ⋯ High LAS are associated with worse survival in lung transplant recipients with CF.
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J. Heart Lung Transplant. · Oct 2015
International Society for Heart and Lung Transplantation Donation After Circulatory Death Registry Report.
The objective of this study was to review the international experience in lung transplantation using lung donation after circulatory death (DCD). ⋯ This large study of international, multi-center experience demonstrates excellent survival after lung transplantation using DCD donors. It should be further evaluated whether the mechanism of donor death influences survival after DCD transplant.
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J. Heart Lung Transplant. · Sep 2015
Clinical and demographic factors associated with post-lung transplantation survival in individuals with cystic fibrosis.
Contemporary studies evaluating post-transplant survival are limited and often include data from single centers or selected sub-groups. The purpose of this study was to evaluate overall transplant survival and to identify risk factors associated with death after transplant. ⋯ After lung transplantation, 5-year survival in Canadians with CF is 67%, and 50% of patients live >10 years. Despite these impressive probabilities, age at transplant, pancreatic sufficiency and B cepacia infection remain important determinants of survival after lung transplantation.
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J. Heart Lung Transplant. · Sep 2015
Case ReportsBridge to transplantation with long-term mechanical assist device in adults after the Mustard procedure.
There is limited clinical experience with bridging to transplant with a left ventricular assist device (VAD) in patients with previously palliated transposition of great arteries. ⋯ With the increased prevalence of late post-Mustard heart failure, bridge to transplant with a VAD may be a suitable treatment option for patients who are severely ill.
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J. Heart Lung Transplant. · Jul 2015
Portal and centrilobular hepatic fibrosis in Fontan circulation and clinical outcomes.
The Fontan operation redirects venous blood flow directly to the pulmonary circulation in subjects with single ventricle anatomy. Congestive hepatopathy and cirrhosis have been described in subjects with Fontan circulation, but the prevalence of and predictors for liver disease remain unknown. ⋯ Individuals with Fontan physiology have a high prevalence of hepatic fibrosis. Signs and symptoms of liver disease did not predict histopathologic findings. Few risk factors for advanced disease were identified. Histopathology findings did not predict transplant-free survival. The role of liver biopsy in this population remains uncertain.