The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
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J. Heart Lung Transplant. · May 2011
A novel approach to the assessment of lymphocytic bronchiolitis after lung transplantation--transbronchial brush.
Lymphocytic bronchiolitis (LB) is the strongest risk factor for subsequent allograft loss due to bronchiolitis obliterative syndrome (BOS); however, it is poorly assessed by transbronchial biopsy (TBBx) because of sampling error, interpretation error and the presence of non-alloimmune airway inflammation. We hypothesized that flow cytometric evaluation of bronchiolar brushings (transbronchial brush, TBBr) may be a better approach. ⋯ TBBr is simple to obtain, low risk, quantitative, and can discriminate between infective and alloimmune LB. It may be a valuable addition to current lung allograft assessment.
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J. Heart Lung Transplant. · May 2011
Comparative StudyComparison of pulmonary function test and computed tomography volumetry in living lung donors.
We previously proposed calculating forced vital capacity (FVC) by the number of segments for size matching in living-donor lobar lung transplantation (LDLLT). The primary purpose of this study was to compare spirometry-obtained calculations of lower lobe volumes with three-dimensional (3D) computed tomography (CT) volumetric images. Our second goal was to compare the data of pulmonary function tests with CT volumetry in living lung donors. ⋯ We confirmed that it would be justified to estimate graft FVC by the number of segments according to the CT volumetric data in LDLLT.
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J. Heart Lung Transplant. · Apr 2011
Comparative StudyEffect of donor preservation solution and survival in lung transplantation.
The aim of this retrospective study was to determine whether the type of preservation solution significantly alters outcomes in lung transplantation, with particular emphasis on primary graft dysfunction and mortality. ⋯ Papworth solution for donor lung preservation is associated with an increased mortality in lung transplant recipients.
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Although the world of advanced heart failure has intensely focused its spotlight on mechanical circulatory support, the field of heart transplantation has continued to evolve. We highlight the latest clinical and laboratory research that have affected the field of adult heart transplantation. Major scientific and clinical advances in the field of heart transplantation have focused on expanding the donor pool, refining the use of immunosuppression, and monitoring the effects of therapy.