Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Aug 2009
Evaluating the role of zinc in the occurrence of fibrosis of the skin: a preclinical study.
To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium-based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephrogenic systemic fibrosis (NSF). ⋯ We found no significant effect of Zn on the initiation of NSF-like skin lesions. The results further support data from previous studies highlighting the importance of complex stability of the investigated GBCAs.
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J Magn Reson Imaging · Aug 2009
Myocardial T2 quantitation in patients with iron overload at 3 Tesla.
To investigate the feasibility of measuring myocardial T2 at 3 Tesla for assessment of tissue iron in thalassemia major and other iron overloaded patients. ⋯ Myocardial T2 quantitation is feasible at 3T. Given the substantially decreased T2 and increased B0 inhomogeneity, the rapid myocardial T2 measurement protocol demonstrated here may present a robust alternative to study cardiac iron overload at 3T.
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J Magn Reson Imaging · Aug 2009
Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats.
To determine if differences exist between control and diabetic rats in functional magnetic resonance imaging (fMRI) activity of the spinal cord and if fMRI can provide a means of early detection of diabetic neuropathy. ⋯ The results of this study are consistent with reports that primary afferent input to the spinal cord is diminished by diabetes, and suggest that BOLD fMRI may be useful in early detection of diabetic neuropathy.
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J Magn Reson Imaging · Aug 2009
Comparative StudyDetection and characterization of focal hepatic tumors: a comparison of T2-weighted MR images before and after the administration of gadoxectic acid.
To evaluate if T2-weighted images (T2WI) after administration of gadoxetic acid have diagnostic capability comparable to precontrast T2WI in the detection and characterization of focal liver lesions. ⋯ Gadoxetic acid-enhanced T2WIs showed a comparable diagnostic capability to precontrast T2WIs for the detection and characterization of hepatic tumors.
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J Magn Reson Imaging · Aug 2009
Prostate cancer detection with multi-parametric MRI: logistic regression analysis of quantitative T2, diffusion-weighted imaging, and dynamic contrast-enhanced MRI.
To develop a multi-parametric model suitable for prospectively identifying prostate cancer in peripheral zone (PZ) using magnetic resonance imaging (MRI). ⋯ Using logistic regression, an objective model capable of mapping PZ tumor with reasonable performance can be constructed.