Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Nov 2004
Discovery and disclosure of incidental findings in neuroimaging research.
To examine different protocols for handling incidental findings on brain research MRIs, and provide a platform for establishing formal discussions of related ethical and policy issues. ⋯ Guidelines for minimum and optimum standards for detecting and communicating incidental findings on brain MRI research are needed.
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J Magn Reson Imaging · Nov 2004
Diffusion-weighted imaging of the parotid gland: Influence of the choice of b-values on the apparent diffusion coefficient value.
To determine how the ADC value of parotid glands is influenced by the choice of b-values. ⋯ The ADC values calculated from low b-value settings were significantly higher than those calculated from high b-value settings. These results suggest that not only true diffusion but also perfusion and saliva flow may contribute to the ADC.
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J Magn Reson Imaging · Nov 2004
MRI monitoring of Avastin antiangiogenesis therapy using B22956/1, a new blood pool contrast agent, in an experimental model of human cancer.
To evaluate the diagnostic and prognostic potential of a new protein-binding contrast medium, B22956/1, for quantitatively characterizing tumor microvessels by MRI and monitoring response to antiangiogenic therapy. ⋯ With the use of appropriate contrast media, the therapeutic effects of an anti-VEGF antibody on tumor microvessels can be monitored by dynamic MRI. The dynamic range of permeability to B22956/1, and the sensitivity to change of this parameter suggest a potential application in the clinical setting.
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J Magn Reson Imaging · Nov 2004
Clinical TrialCan the apparent diffusion coefficient be used as a noninvasive parameter to distinguish tumor tissue from peritumoral tissue in cerebral gliomas?
To determine whether the apparent diffusion coefficient (ADC) can be used to distinguish between tumor tissue and peritumoral brain tissue in cerebral gliomas. ⋯ The ADC is not helpful for distinguishing tumor tissue from peritumoral brain tissue in gliomas.
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J Magn Reson Imaging · Nov 2004
Quantitative proton MR spectroscopic imaging of the mesial temporal lobe.
To evaluate variations in regional metabolite concentrations in the anterior mesial temporal lobe (ATL), and compare metabolite concentrations between the allocortex and neocortex using quantitative proton MR spectroscopic imaging (MRSI). ⋯ The mesial temporal lobe shows high levels of Cho, which presumably reflect a difference in cellular composition between the allocortex and neocortex. Regional metabolite variations must be considered when pathological conditions involving the mesial temporal lobe are evaluated.