Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
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Anasthesiol Intensivmed Notfallmed Schmerzther · Apr 2012
[Pharmacologic thromboprophylaxis in critically ill patients].
Critical care patients have to be considered at high risk patients for thromboembolic events. The recommendations and guidelines support strongly a pharmacologic anticoagulant prophylaxis. ⋯ In case of acutely suspected or diagnosed HIT type II Argatroban seems to be a reasonable choice for anticoagulation. The new orally available anticoagulant drugs are not yet indicated in ICU patients.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Apr 2012
[Safe use of cuffed tracheal tubes in children].
In the last 5 years the use of cuffed tracheal tubes in infants and children has become popular worldwide and is accepted by major medical authorities. The advantages of cuffed tracheal tubes in smaller children - in particular the almost 100% chance to insert the right sized tracheal tube at the first attempt and their reliable sealing characteristics within the trachea - makes tracheal intubation and ventilation considerable easier and safer. ⋯ Conditions for the safe use of cuffed tubes in children are the availability of an adequately designed cuffed tube with a proofed recommendation for tube size selection and cuff pressure monitoring. The following rules must be fulfiled when cuffed tubes in children using are: confirmation of an air leak < 20 cmH2O inspiratory pressure with the cuff not inflated, cuff pressure limitation at 20 cmH2O and the avoidance of negative cuff pressures, resulting in sharp, cutting edges of the cuff membrane within the trachea.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Apr 2012
[Mental disorders in intensive care medicine - Part 2: Prevention and therapeutic approaches].
This two part article "Mental disorders in intensive care medicine" aims to give an understanding of the most frequent mental disorders in critical care medicine. Part 1 highlights the basics, disturbances and diagnostics, part 2 prevention and therapeutic approaches.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Apr 2012
[Opioid effects - galenics make the difference].
The galenics of extended-release opioids is highly variable and often insufficently. The quality of retard formulations can roughly be evaluated by means of 3 parameters: 1. PTF-Value (peak-trough fluctuation) [PTF (%) = [Cmax - Cmin] ×100/Cav] which should be as small as possible in order to minimize the fluctuation of plasma levels e.g. ⋯ A too short HVD can induce end-of-dose-failure. HVD of most opioid formulations (b.i.d.) is only 6h, better are Morphin-KREWEL® with a HVD of 8,4h and especially Jurnista® (q.d.) with HVD =21,8h. These different galenics ban a so-called "Aut-idem-Substitution" of extended-release opioids.