Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Aug 1994
Effects of atrial natriuretic peptide on renal function after cardiac surgery and in cyclosporine-treated heart transplant recipients.
The study investigated the effects of intravenous infusion of atrial natriuretic peptide (human ANP 99-126) on renal function and central hemodynamics after coronary artery bypass grafting (CABG), and the ability of ANP to reverse the acute nephrotoxic effects of cyclosporine after heart transplantation. Ten patients with an EF > 0.5 and normal renal function were studied 2 to 4 hours after CABG surgery. Furthermore, six heart transplant recipients receiving cyclosporine for immunosuppression who developed renal dysfunction 2 to 4 days after transplantation were studied. ⋯ In the heart transplant recipients, baseline GFR was markedly reduced compared to pretransplantation values (-65%). UF, GFR, and RBF increased 240%, 69%, and 53%, respectively, while renal vascular resistance decreased 45% during the highest dose of ANP infused. At this ANP dose level, circulating ANP concentrations were sixfold to eightfold higher than the preinfusion control level.(ABSTRACT TRUNCATED AT 250 WORDS)
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J. Cardiothorac. Vasc. Anesth. · Aug 1994
Use of monitoring devices during anesthesia for cardiac surgery: a survey of practices at public hospitals within the United Kingdom and Ireland.
A questionnaire was sent to all 42 public hospitals, within the United Kingdom (UK) and Ireland, known to conduct elective cardiac surgery. Information was sought with regard to the availability of intraoperative monitoring equipment. ⋯ Similarly, continuous monitoring of arterial oxygen tension and oxygen fraction in the gas flow to the bypass machine was not conducted in 28 and 32 hospitals, respectively. This survey revealed that essential anesthetic monitoring devices, as defined by the United Kingdom Association of Anesthetists, are not in routine usage during the pre-bypass and post-bypass phases of anesthesia for cardiac surgery within the British Isles.