Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Aug 2008
Comparative StudyClosed-loop control of consciousness during lung transplantation: an observational study.
To determine if propofol infusion can be steered automatically by using bispectral index (BIS) as a controller during lung transplantation. ⋯ Closed-loop control of consciousness by a computer during lung transplantation is clinically feasible.
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J. Cardiothorac. Vasc. Anesth. · Aug 2008
Comparative StudyReactive oxygen species and mitochondrial adenosine triphosphate-regulated potassium channels mediate helium-induced preconditioning against myocardial infarction in vivo.
Helium produces preconditioning by activating prosurvival kinases, but the roles of reactive oxygen species (ROS) or mitochondrial adenosine triphosphate-regulated potassium (K(ATP)) channels in this process are unknown. The authors tested the hypothesis that ROS and mitochondrial K(ATP) channels mediate helium-induced preconditioning in vivo. ⋯ The results suggest that ROS and mitochondrial K(ATP) channels mediate helium-induced preconditioning in vivo.
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J. Cardiothorac. Vasc. Anesth. · Aug 2008
Comparative StudyRisk factors for failed "fast-tracking" after cardiac surgery in patients older than 70 years.
"Fast-track" pathways have been successfully used in low-risk, relatively young patients after all types of surgical procedures including cardiac surgery. An increase in the number of referrals of older patients for cardiac surgery prompted the present study on the use of a "fast-track" pathway in septuagenarians and octogenarians. Risk factors for the unsuccessful application of the "fast-track" pathway in these elderly patients were determined. ⋯ A "fast-track" pathway may be applied in selected septuagenarians and octogenarians. Age alone should not exclude consideration for "fast-track" management.
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J. Cardiothorac. Vasc. Anesth. · Aug 2008
Comparative StudyThe concentration-dependent contractile effect of methylene blue in the human internal mammary artery: a quantitative approach to its use in the vasoplegic syndrome.
To quantitate the contractile effect of methylene blue on isolated human internal mammary artery (IMA) as used in the vasoplegic syndrome. ⋯ Methylene blue caused concentration-dependent contraction in human IMAs. Furthermore, the inhibition of ACh-induced relaxation for 6 hours after the methylene blue challenge points out an additional mechanism (ie, receptor occupation). The concentration-dependent contractile effect of methylene blue justifies its use in the vasoplegic syndrome. The findings also suggest that the time course of contraction is longer than the exposure to methylene blue.