Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Feb 2013
Effect of cardiopulmonary bypass on thrombin generation and protein C pathway.
The purpose of this study was to evaluate the mechanisms of cardiopulmonary bypass (CPB)-induced dysregulation between thrombin and its regulatory anticoagulant activated protein C (APC). ⋯ Exposure to CPB is associated with a distinct thrombin surge that continues postoperatively for 4 hours. The impaired ability to generate APC reflects a complex process that is not associated with increased levels of sEPCR and thrombomodulin during CPB. Further studies are required to evaluate the regulation of the host APC response in cardiac surgery.
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J. Cardiothorac. Vasc. Anesth. · Feb 2013
Sevoflurane requirement to maintain bispectral index-guided steady-state level of anesthesia during the rewarming phase of cardiopulmonary bypass with moderate hypothermia.
The authors aimed to quantify any increase and the extent of the increase in sevoflurane requirements for maintaining hypnosis during hypothermic cardiopulmonary bypass (CPB) with the bispectral index (BIS) maintained between 40 and 50. ⋯ The sevoflurane requirement increases during the rewarming phase of hypothermic CPB. The percent increase in the requirement for sevoflurane is uniform and follows a particular pattern, which may be predicted.