Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Dec 2020
Apolipoprotein L1 (APOL1) Coding Variants Are Associated With Creatinine Rise After Cardiac Surgery.
Acute kidney injury (AKI) is a complication of cardiac surgery that is considerably more common in African Americans (1.5-fold). Although homozygous status for apolipoprotein L1 (APOL1) risk alleles is associated with chronic kidney disease in individuals of African ancestry, whether these coding variants confer AKI risk is unknown. The present study examined whether APOL1 homozygous risk allele status was associated with AKI in African Americans after cardiac surgery. ⋯ African American cardiac surgery patients homozygous for APOL1 chronic kidney disease risk variants averaged a more than 2-fold higher postoperative creatinine rise even after adjustment for other risk factors, suggesting these alleles also are independent risk factors for AKI.
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J. Cardiothorac. Vasc. Anesth. · Dec 2020
Using Machine Learning to Predict Acute Kidney Injury After Aortic Arch Surgery.
Machine learning models were compared with traditional logistic regression with regard to predicting kidney outcomes after aortic arch surgery. ⋯ Machine learning methods were found to predict AKI after aortic arch surgery significantly better than traditional logistic regression.