Journal of cardiothoracic and vascular anesthesia
-
J. Cardiothorac. Vasc. Anesth. · Dec 2010
Changing from aprotinin to tranexamic acid results in increased use of blood products and recombinant factor VIIa for aortic surgery requiring hypothermic arrest.
Aprotinin, once used to reduce allogeneic blood product transfusion during cardiac surgery, was withdrawn from the market in late 2007 over concerns of causing increased mortality. This study was undertaken to determine what, if any, the impact of changing antifibrinolytic agents (from aprotinin to tranexamic acid) for deep hypothermic circulatory arrest cases would have on blood bank resource utilization. ⋯ Patients treated with tranexamic acid required more clotting factors than the control group receiving aprotinin.
-
J. Cardiothorac. Vasc. Anesth. · Dec 2010
Randomized Controlled TrialEarly postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery.
To test the hypothesis that perioperative statin use reduces acute kidney injury (AKI) after cardiac surgery. ⋯ Early postoperative statin use is associated with a lower incidence of AKI among both chronic statin users and statin-naive cardiac surgery patients.
-
J. Cardiothorac. Vasc. Anesth. · Dec 2010
History of post-traumatic stress disorder is associated with impaired neuropsychometric performance after coronary artery surgery.
To determine if preoperative history of post-traumatic stress disorder (PTSD) is associated with postoperative cognitive impairment. ⋯ The current findings suggest that patients with a history of PTSD undergoing coronary artery surgery using cardiopulmonary bypass may be especially vulnerable to postoperative cognitive impairment.