International journal of antimicrobial agents
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Int. J. Antimicrob. Agents
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Int. J. Antimicrob. Agents · Apr 2015
Editorial CommentAugmented renal clearance and therapeutic monitoring of β-lactams.
Successful application of antibacterial therapy in the critically ill requires an appreciation of the complex interaction between the host, the causative pathogen and the chosen pharmaceutical. A pathophysiological change in the intensive care unit (ICU) patient challenging the 'one dose fits all' concept includes augmented renal clearance (ARC), defined as a creatinine clearance (CL(Cr)) of ≥130 mL/min. ⋯ One way to document and alter drug levels is via therapeutic drug monitoring (TDM). The interactions of ARC and β-lactam TDM are further explored in this article in specific reference to a concomitant article in this issue of the journal.