International journal of obstetric anesthesia
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Int J Obstet Anesth · Oct 1995
Effect of dantrolene sodium on contractility of isolated human uterine muscle.
The administration of intravenous dantrolene in a parturient susceptible to malignant hyperthermia has been associated with post partum uterine atony. We examined the effect of dantrolene sodium for injection (Dantrium Intravenous) on spontaneous contractility of uterine smooth muscle from women in term pregnancy in an isolated preparation. Dantrolene sodium for injection at 5 microg/ml and 10 microg/ml had no effect on the spontaneous contractility of the uterine muscle preparations. ⋯ However, a similar depression in the muscle preparations treated with mannitol suggests that the depression observed with the dantrolene was likely due to the mannitol that was included in the dantrolene formulation rather than to dantrolene sodium itself. We conclude that dantrolene sodium has no effect on the spontaneous contractility of uterine smooth muscle. The depression of uterine muscle activity observed with dantrolene for injection appears attributable to the mannitol.
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In 1993 a postal survey of maternity hospitals within the UK was carried out to obtain data on the types of anaesthesia used for caesarean section. The poor response rate (79/226, 35%) reflects the paucity of data available in many centres. ⋯ Overall, during the 11-year period covered by the survey there was a significant reduction in the percentage use of general anaesthesia (77% in 1982 declining to 44% in 1992), but because of a 51% increase in the caesarean section rate the real reduction in the actual number of general anaesthetics used was modest (13%). If this holds true nationally, then factors other than a simple change from general anaesthesia to regional anaesthesia must contribute to the reduced maternal mortality from anaesthetic causes.