Acta paediatrica
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Randomized Controlled Trial
Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia.
Serum S100B and neuron-specific enolase (NSE) levels are elevated after perinatal asphyxia, but the influence of hypothermia on these proteins has not been previously reported. The aim of this study was to evaluate the effect of systemic hypothermia on these protein levels after perinatal asphyxia, time course, and association with perinatal factors and neurodevelopmental outcome at 2 years of age. ⋯ Both NSE and S100B levels are highly elevated following asphyxia. Serum S100B levels were lower in the HT group and strongly correlated with the neurodevelopmental outcome.
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Randomized Controlled Trial
Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study.
To compare the efficacy of sublingual midazolam with oral morphine versus that of oral morphine with placebo in a paediatric population attending an emergency department (ED) with acute long-bone fractures. ⋯ The analgesic performances of morphine and the combination of morphine with midazolam assessed by VAS were similar in children presenting at the ED with a long-bone fracture.
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Randomized Controlled Trial Multicenter Study Comparative Study
Hypotonic versus isotonic maintenance fluids in critically ill children: a multicenter prospective randomized study.
Study the influence of hypotonic (HT) and isotonic (IT) maintenance fluids in the incidence of dysnatraemias in critically ill children. ⋯ Hypotonic maintenance fluids increase the incidence of hyponatraemia because they decrease blood sodium levels in normonatraemic patients. IT maintenance fluids do not increase the incidence of dysnatraemias and should be considered as the standard maintenance fluids.
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Randomized Controlled Trial Comparative Study Clinical Trial
Neopuff T-piece mask resuscitator: is mask leak related to watching the pressure dial?
The aim of the study is to compare mask leak and delivered ventilation during Neopuff (NP) mask ventilation in two modes: (i) with NP pressure dial hidden and resuscitator watching chest wall (CW) rise with, (ii) CW movement hidden and resuscitator watching NP pressure dial. ⋯ This study provides reassurance that NP mask leak is not greater when resuscitators watch the NP pressure dial. Mask leak is related to TVe. Mask ventilation training with manikins should include tidal volume measurements.
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Randomized Controlled Trial Comparative Study
Early nasal intermittent positive pressure ventilation versus continuous positive airway pressure for respiratory distress syndrome.
To determine whether early nasal intermittent positive pressure ventilation (NIPPV), in comparison to early continuous positive airway pressure (CPAP), can reduce the need for intubation and mechanical ventilation in preterm neonates with suspected respiratory distress syndrome (RDS). ⋯ Among preterm infants with suspected RDS, early use of NIPPV reduces the need for intubation and mechanical ventilation compared to CPAP.