Paediatric anaesthesia
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Paediatric anaesthesia · Dec 2011
Effects of hemodilution after traumatic brain injury in juvenile rats.
Normovolemic hemodilution (HD) in adult animal studies has shown exacerbation of traumatic brain injury (TBI) lesion volumes. Similar studies in juvenile rats have not been reported and outcomes are likely to be different. This study investigated the effects of normovolemic hemodilution (21% hematocrit) in a juvenile TBI (jTBI) model. ⋯ Hemodilution results in significant brain hyperemia with increased edema formation, extravascular blood volume, and water mobility after jTBI. Hemodilution results in less cortical damage but did not alter behavior. Hemodilution is likely not to be clinically beneficial following jTBI.
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Paediatric anaesthesia · Dec 2011
Erythropoietin attenuates isoflurane-induced neurodegeneration and learning deficits in the developing mouse brain.
To examine whether recombinant erythropoietin (rEPO) attenuates neurodegeneration and the learning disability induced by isoflurane with the postnatal day 7 (P7) mice. ⋯ These results suggested that rEPO attenuated isoflurane-induced neurodegeneration.