American journal of obstetrics and gynecology
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Am. J. Obstet. Gynecol. · Apr 2011
Multicenter Study Clinical TrialImproving pregnancy drug warnings to promote patient comprehension.
We sought to evaluate the effectiveness of a pharmaceutical labeling strategy intended to improve comprehension of a teratogen warning. ⋯ In our study, a teratogen warning label that had easy-to-read messages with icons significantly improved comprehension.
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Am. J. Obstet. Gynecol. · Dec 2010
Randomized Controlled Trial Multicenter Study Comparative StudyEffectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy. ⋯ Diclectin delayed release formulation of doxylamine succinate and pyridoxine hydrochloride is effective and well tolerated in treating nausea and vomiting of pregnancy.
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Am. J. Obstet. Gynecol. · Oct 2008
Randomized Controlled Trial Multicenter Study Comparative StudyFerric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: a randomized controlled clinical trial.
The objective of the study was to evaluate the efficacy, safety, and tolerability of intravenous ferric carboxymaltose, compared with oral ferrous sulfate in women with postpartum anemia. ⋯ Intravenous ferric carboxymaltose was safe and well tolerated with an efficacy superior to oral ferrous sulfate in the treatment of postpartum iron deficiency anemia.
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Am. J. Obstet. Gynecol. · Jan 2008
Multicenter StudyFetal lung volume after endoscopic tracheal occlusion in the prediction of postnatal outcome.
The objective of the study was to investigate the volume response of the contralateral lung in the prediction of postnatal outcome in fetuses with congenital diaphragmatic hernia (CDH) treated by fetoscopic endotracheal occlusion (FETO). ⋯ In fetuses with CDH, the lung responsiveness within 2 and 7 days after FETO provides useful prediction of subsequent survival.
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Am. J. Obstet. Gynecol. · Oct 2007
Multicenter StudyAssociations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption.
Heritable thrombophilias have been implicated as a potential cause of abruption by vascular disruption at the uteroplacental interface. Polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene have been linked to vascular complications outside of pregnancy, which includes stroke. Given the underlying thrombotic nature of abruption, we hypothesized that polymorphisms in the MTHFR gene are associated with abruption. ⋯ In this population, neither heterozygosity nor homozygosity for the 677C-->T and 1298A-->C variants in MTHFR was associated with placental abruption.