Surgical oncology clinics of North America
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Surg. Oncol. Clin. N. Am. · Jan 2009
ReviewManagement of familial melanoma and nonmelanoma skin cancer syndromes.
The clinical manifestations of hereditary skin cancer syndromes depend upon the interplay between environmental and genetic factors. Familial melanoma occurs in the setting of hereditary susceptibility, with a complex phenotype of early age of onset, multiple atypical moles, multiple primary melanomas, multiple melanomas in the family, and in some instances pancreatic cancer. ⋯ Consequently, the surgeon as one of the primary caregivers should be familiar with hereditary skin cancer syndromes and their pathogenesis, diagnosis, management, and surveillance recommendations. This article discusses a practical approach for some of the issues likely encountered by the surgeon in the management of familial melanoma and non-melanoma skin cancer.
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Surg. Oncol. Clin. N. Am. · Jan 2009
ReviewThyroid cancer genetics: multiple endocrine neoplasia type 2, non-medullary familial thyroid cancer, and familial syndromes associated with thyroid cancer.
Familial thyroid cancer accounts for 25% of medullary thyroid cancer (MTC) and 5% of non-medullary thyroid cancer. All patients who have familial MTC have one of three variants of multiple endocrine neoplasia type 2 that are defined by specific mutations in the rearranged during transfection (RET) proto-oncogene. ⋯ Thyroid cancer also is associated with a number of familial syndromes. This article focuses on the genetics and management of familial thyroid cancers and the syndromes associated with thyroid cancer.
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Surg. Oncol. Clin. N. Am. · Jul 2008
ReviewLaparoscopic resection for colorectal cancer: evidence to date.
This article highlights the individual merits and weaknesses of laparoscopic as compared with open surgery as the primary treatment of colorectal cancer. Although results clearly suggest that laparoscopic surgery for colorectal cancer results in an earlier postoperative recovery, it is more difficult to comment on rarer complications. To date, results from laparoscopic colorectal resections suggest that the resected specimen is oncologically comparable that obtained with open surgery, but more long-term data on cancer recurrence and survival at 3 and 5 years postoperatively are eagerly awaited.
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Surg. Oncol. Clin. N. Am. · Apr 2008
ReviewMolecular pathology--translating research into clinical practice: an expanding frontier in surgical oncology.
Molecular assays have now become essential to the pathologist and clinician alike in diagnosing and managing disease. This article highlights the techniques and molecular targets no longer ancillary to basic research. ⋯ Molecular methods are forecasted to increase in assisting in the diagnosis of human diseases. The author's mission is to embrace this discipline and use these technologies in clinical practice.
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Surg. Oncol. Clin. N. Am. · Jan 2007
ReviewGastric cancer: D2 dissection or low Maruyama Index-based surgery--a debate.
This article provides perspectives on the surgical approaches required optimally to manage patients with respectable gastric adenocarcinoma. The status of techniques of surgical resection in the management of gastric cancer is reviewed. The premise of this approach is that extended gastrectomy with D2 lymph node dissection is good. Also addressed are prognostic and predictive factors in the surgical treatment of stomach cancer.