The American journal of psychiatry
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Randomized Controlled Trial Comparative Study Clinical Trial
A double-blind comparative study of clozapine and risperidone in the management of severe chronic schizophrenia.
This prospective, double-blind, multicenter, parallel-group study compared the efficacy and safety of therapeutic doses of clozapine and risperidone in patients with severe chronic schizophrenia and poor previous treatment response. ⋯ Clozapine showed superior efficacy over risperidone in this patient population. Both treatments were equally well tolerated as demonstrated through their adverse event profiles, although as expected clozapine was associated with a lower risk of extrapyramidal symptoms than risperidone.
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Randomized Controlled Trial Comparative Study Clinical Trial
Day treatment versus enhanced standard methadone services for opioid-dependent patients: a comparison of clinical efficacy and cost.
This study examined the differential efficacy and relative costs of two intensities of adjunctive psychosocial services--a day treatment program and enhanced standard care--for the treatment of opioid-dependent patients maintained on methadone hydrochloride. ⋯ Providing an intensive day treatment program to unemployed, inner-city methadone patients was not cost-effective relative to a program of enhanced methadone maintenance services, which produced comparable outcomes at less than half the cost.
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Randomized Controlled Trial Clinical Trial
Double-blind, fixed-dose, placebo-controlled study of paroxetine in the treatment of panic disorder.
This study was designed to determine the minimum paroxetine dose effective for treating panic disorder. ⋯ Paroxetine is an effective and well-tolerated short-term treatment of panic disorder. The minimum dose demonstrated to be significantly superior to placebo was 40 mg/day, although some patients did respond at lower doses.
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Randomized Controlled Trial Clinical Trial
Lithium treatment of conduct disorders in adolescents.
The authors examined the efficacy of lithium carbonate for treating conduct disorder in adolescents. ⋯ Lithium does not appear beneficial for this indication.
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Randomized Controlled Trial Comparative Study Clinical Trial
Cognitive behavior therapy for chronic fatigue syndrome: a randomized controlled trial.
Cognitive behavior therapy for chronic fatigue syndrome was compared with relaxation in a randomized controlled trial. ⋯ Cognitive behavior therapy was more effective than a relaxation control in the management of patients with chronic fatigue syndrome. Improvements were sustained over 6 months of follow-up.