The American surgeon
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The American surgeon · Jan 2012
ReviewSepsis, systemic inflammatory response, and multiple organ dysfunction: the mystery continues.
Human sepsis is thought to be systemic inflammatory response syndrome (SIRS) that is activated by invasive infection. The multiple organ dysfunction syndrome (MODS) is the identified failure of critical organ function in patients that have sustained SIRS. Because SIRS and MODS are consequences of the excessive activation of inflammation, extensive research and numerous clinical trials have pursued treatments that would modify the inflammatory response. ⋯ Clinical trials with biomodulators to block or inhibit inflammation have generally failed to improve the outcomes in patients with severe sepsis, septic shock, and MODS. The role of counter-inflammatory signaling and the newer concept of the cholinergic anti-inflammatory pathway are being investigated, and newer hypotheses are focusing upon the balancing of proinflammatory and counter-inflammatory mechanisms as important directions for newer therapies. It is concluded that failure to define novel and effective treatments reflects fundamental gaps in our understanding of inflammation and its regulation.
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The American surgeon · Nov 2011
ReviewRole of high-intensity focused ultrasound in treatment of hepatocellular carcinoma.
About 70 per cent of patients with hepatocellular carcinoma are diagnosed at intermediate or advanced stages, and most of them are technically unresectable. As a novel, emerging therapeutic modality, high intensity focused ultrasound (HIFU) has a great potential for tumor treatment. In this review, principle of HIFU technique is introduced, and an overview of clinical applications and limitations of HIFU for HCC treatment, as well as prospects for future development, is provided. Consequently, HIFU has been considered a safe and feasible procedure for HCC treatment.
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The American surgeon · Sep 2011
Review Meta AnalysisSutures versus staples for the management of surgical wounds: a meta-analysis of randomized controlled trials.
Surgical sutures are conventionally used in skin closure of surgical wounds. Alternative wound closure techniques include staples and adhesive strips. We aimed to evaluate sutures versus staples as methods of surgical wound closure by performing a meta-analysis. ⋯ Our findings suggest that staples are associated with fewer wound infections compared with sutures in the evaluated types of surgery. However, in a rather limited number of studies, the use of staples was associated with more pain. Further studies incorporating more objective methods for assessment cosmetic and patient satisfaction are required to clarify this issue.
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The American surgeon · Jul 2011
ReviewResuscitation in intra-abdominal hypertension and abdominal compartment syndrome.
Resuscitation and the development of abdominal compartment syndrome (ACS) are closely associated and frequently overlapping critical care topics. Elevated intra-abdominal pressure (IAP) can cause major deterioration of cardiac function by affecting preload, contractility, and afterload. ⋯ Excessive or overzealous resuscitation in an attempt to restore perfusion and correct these organ dysfunctions and failures can worsen elevated IAP and increase the risk of ACS. The aim of this review is to discuss these multilevel interactions between resuscitation and ACS identifying appropriate resuscitative strategies for the patient with elevated IAP.
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The American surgeon · Jul 2011
ReviewIntra-abdominal hypertension and abdominal compartment syndrome in the medical patient.
Critically ill medical patients are at significant risk for developing intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). Although surgical IAH/ACS is commonly acute and dramatic in onset, medical IAH/ACS is more slow and insidious in its development but no less deadly. ⋯ A variety of effective medical management strategies for reducing elevated intra-abdominal pressure (IAP), coupled with early abdominal decompression when necessary, has been demonstrated to significantly improve patient survival from IAH/ACS. Serial IAP measurements, increased collaboration between surgeon and nonsurgeon, institution of medical management strategies, and early abdominal decompression for refractory IAH/ACS will lead to decreased rates of organ failure and improved survival for medical patients who develop IAH/ACS.