Der Anaesthesist
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Approximately 5-8 million people in Germany suffer from chronic pain. Some patients can obtain relief from specific interventional techniques. In detail these are blocks of the sympathetic chain and peripheral nerve blocks, regional anesthetic techniques close to the spinal cord and neuromodulation. ⋯ Peripheral nerve blocks are important for postoperative pain treatment. Only a few methods are used for chronic pain and this applies primarily to the intercostal block which is used for the treatment of pain occurring after thoracotomy, intercostal neuralgia and pain associated with infiltration of cancer. Blocks of the vegetative nervous system are accomplished on the ganglions of the head and the sympathetic chain and are therefore most commonly applied to treat headache, neuropathic and sympathetic pain in the area of abdomen and the extremities.
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Volume substitution represents an essential component of intensive care medicine. The amount of fluid administered, the composition and the timing of volume replacement seem to affect the morbidity and mortality of critically ill patients. Although restrictive volume strategies bear the risk of tissue hypoperfusion and tissue hypoxia in hemodynamically unstable patients liberal strategies favour the development of avoidable hypervolemia with edema and resultant organ dysfunction. ⋯ As the efficiency of volume resuscitation for correction of tissue hypoxia is time-dependent, preload optimization should be completed in the very first hours. Whether colloids or crystalloids are more suitable for this purpose is still controversially discussed. Nevertheless, a temporally limited use of colloids during the initial stage of tissue hypoperfusion appears to represent a strategy which uses the greater volume effect during hypovolemia while minimizing the risks for adverse reactions.
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Randomized Controlled Trial
Hemodynamics in coronary artery bypass surgery: effects of intraoperative dexmedetomidine administration.
Dexmedetomidine is an α2-receptor agonist which is increasingly being used in coronary artery bypass grafting (CABG) surgery due to its suppressive effect on the stress responses against intubation and surgery. In this study effects of dexmedetomidine administration as an adjuvant agent during induction and maintenance of anesthesia on intraoperative hemodynamic changes were studied in patients undergoing CABG. ⋯ Dexmedetomidine can be safely used in CABG operations delivering a stable hemodynamic status throughout the operative period.