Der Anaesthesist
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The current guidelines of the European Resuscitation Council recommend targeted temperature management to improve functional neurological outcome in comatose survivors after cardiac arrest. With the pathophysiological background of hypothermia-induced neuroprotection for prevention of hypoxic-ischemic encephalopathy, targeted temperature management is a key measure and represents a central aspect in postresuscitation care. In the 2021 guidelines the application of targeted temperature management in postresuscitation care has been recommended for all rhythms and irrespective of the location of cardiac arrest. ⋯ Furthermore, recent data on preclinical management, different patient populations, the duration of targeted temperature management, cooling methods and rebound hyperthermia are discussed. The impact of targeted temperature management on neurological outcome after cardiac arrest has been a matter of controversy. Despite contradictory results and heterogeneity of study designs, the current evidence supports the relevance and the necessity of strict temperature control in postresuscitation care for neuroprotection and improvement in functional neurological outcomes.
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In 1981 the Canadian Peter Stewart presented a new concept for the interpretation of the acid-base balance. Rehm et al. published the first German language article on this topic. ⋯ This gap is intended to be filled by this work. It introduces a simple, practical algorithm and provides an approach to understanding the acid-base balance and the Stewart concept, which assumes that the plasma ions determine the pH value and the base excess (BE) in the plasma.
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Review
[Intensive Care ventilation-New norm establishes a uniform nomenclature for ventilation modes].
The current naming of ventilation modes in anesthesiology and critical care is characterized by manufacturer-specific inconsistent acronyms. This is confusing for users and potentially life-threatening for patients. The standard, published in August 2021 in its German version as DIN EN ISO 19223:2021, aims to introduce a uniform classification with corresponding nomenclature. ⋯ Standardized terminology and semantics in respiratory care are necessary and desirable for error reduction. However, the recently presented standard fulfils these expectations only to some extent and in its current form will probably lead to further ambiguities and problems in the clinical routine. Accordingly, it is imperative that this first version of DIN EN ISO 19223:2021 be understood as the starting point for a discussion of its content, even outside the standards committees, so that its obvious weaknesses can be eradicated and the nomenclature made suitable for everyday use.
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To date no biomarker has been identified bringing together perfect sensitivity and specificity to discriminate between inflammation and infections. Since the 1930s new markers of tissue damage and endothelial damage have been identified but which are incapable of identifying infections in every clinical setting to enable initiation of early antibiotic treatment. In this review the most important classical biomarkers and upcoming new PCR-based approaches are addressed. ⋯ The issue of discrimination between inflammation and infection is not yet solved. Based on one single biomarker it is impossible to decide whether infection is the reason for the patient's worsening condition but the combination of biomarkers or the integration of new biomarkers may be a meaningful supplement. The measurement of different biomarkers of infection or inflammation is part of the routine in critical care and will be essential in the future.