Der Anaesthesist
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Randomized Controlled Trial Clinical Trial Controlled Clinical Trial
Postoperative nausea and vomiting treated with domperidone (r 33812) an open and a double-blind study.
The effect of domperidone on postoperative nausea and vomiting was evaluated in two consecutive studies. Fifty-eight patients with postoperative nausea and vomiting were included in an open pilot study and 38 other patients in a double-blind trial. ⋯ In the double-blind trial, vomiting recurred significantly later in domperidone than in placebo-treated patients. Side-effects were not seen nor reported in either study.
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Randomized Controlled Trial Comparative Study Clinical Trial
[Subjective complaints of out-patients after halothane or enflurane anaesthesia (author's transl)].
In a prospective and randomized study, day-patients receiving halothane or enflurane-anaesthesia (n = 42 resp. 59) were followed up by questionnaire to detect subjective complaints. There was no difference between the two anaesthetic agents. Despite the high incidence of complaints (88%), most of the patients would choose day-stay care (75%) and general anaesthesia (77%) again.
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Randomized Controlled Trial Clinical Trial
Bupivacaine in caudal anaesthesia for anal surgery.
A study is described of 100 consecutive patients given a caudal block for anal surgery using either 0.25% or 0.5% bupivacaine with adrenaline. The initial success rate was 91%, and a further 8% achieved only a unilateral block. Satisfactory anaesthesia in these cases could be achieved with either a second caudal block or unilateral infiltration of the un-anaesthetized half of the surgical field with lignocaine. ⋯ No serious complications were observed. Post-operative analgesia lasted between 10 and 12 h after the block and this compared favourably with the results from two small control groups given either a general anaesthetic or a lignocaine caudal block in which the patients required analgesics 2,5 and 4,5 h respectively from the start of the anaesthetic procedure. In the bupivacaine treated patients there was a significant reduction in the need for post-operative analgesics throughout the whole postoperative period.
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Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial
[Effects of diazepam and flunitrazepam on the undesired postoperative side-effects of ketamine anaesthesia (author's transl)].
150 patients undergoing minor gynaecological procedures (curretages) were anesthetized with ketamine and either diazepam flunitrazepam or placebo in order to establish the best combination for the prevention of postoperative psychotomimetic effects. From observations, up to 24 h after operation, it was found and statistically proven that the combination of ketamine/flunitrazepam as compared to the combinations ketamine/diazepam and ketamine/placebo led to a remarkable reduction of psychotomimetic side reactions.
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Randomized Controlled Trial Comparative Study Clinical Trial
Venous pain and involuntary muscular movements during and after administration of etomidate. A comparison of two different formulations.
Anaesthesia was induced in 209 patients with etomidate, using either the two vidal formulation, i.e. a solution of 30 mg etomidate sulphate in 20 ml phosphate buffered solution or the new formulation i.e. 5ml ampoules containing 2% etomidate base in polyethylene glycol 1000 (PEG 1000), a ready-for-use solution. Amongst patients who received the two vial formulation of etomidate (n = 105), 26 reported pain on injection as compared with six patients who received etomidate in PEG 1000 (n = 104). In the former group, involuntary muscle movements were reported in 12 patients, three of them being disturbing. In the latter group slight involuntary muscle movements occurred in 15 patients, but were never disturbing.