Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
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To study the hemodynamic effects of exogenously administered endothelin-1 (ET-1), a peptide produced by endothelial cells with potent non-adrenergically mediated vasoconstrictor properties. ⋯ ET-1 is a potent vasoconstrictor. The combination of EPI and ENDO significantly improved CPP compared with that for either agent alone. ET-1 should be investigated further as a vasoconstrictor in cardiac arrest.
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Comparative Study
Glucagon and phenylephrine combination vs glucagon alone in experimental verapamil overdose.
To evaluate glucagon and phenylephrine in combination as a treatment for the hemodynamic effects of verapamil overdose. ⋯ The glucagon/phenylephrine therapy improved MAP compared with the control, but reduced CO and HR compared with glucagon alone. Glucagon/phenylephrine therapy is not as effective as glucagon alone in reversing the hemodynamic effects of experimental verapamil overdose.