Shock : molecular, cellular, and systemic pathobiological aspects and therapeutic approaches : the official journal the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies
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Introduction : Improvements in combat casualty care have increased survival rates, but these patients are at particular risk of developing multiple organ failure (MOF). We investigated the incidence and severity of MOF in a cohort of severe combat casualties. Materials and Methods : This retrospective study included all on-duty French land army war casualties with a severe combat injury requiring intensive care unit admission during 2009-2023. ⋯ A multivariable logistic regression model showed that MOF persistence at day 4 was significantly associated (odds ratios [95% confidence intervals]) with severe injuries (1.5 [1-2.3], P = 0.042). Conclusion : A high number of severe lesions significantly and independently increased risk of MOF persistence at day 4 after combat-related trauma. These findings are particularly relevant to current and anticipated large-scale combat operations that will challenge battlefield casualty care and evacuation.
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Background : The interrelation between the plasma proteome and plasma metabolome with sepsis presents a multifaceted dynamic that necessitates further research to elucidate the underlying causal mechanisms. Methods : Our investigation used public genome-wide association study data to explore the relationships among the plasma proteome, metabolome, and sepsis, considering different sepsis subgroup. Initially, two-sample Mendelian randomization established causal connections between the plasma proteome and metabolome with sepsis. ⋯ Further scrutiny revealed that this plasma metabolite notably augments the abundance of ICAM5 protein ( P value = 3.52E-04, OR = 1.11, 95% CI = 1.04-1.17), devoid of any detected heterogeneity, pleiotropy, or reverse causality. Mediated Mendelian randomization revealed ICAM5 mediated 11.9% of 1,2,3-benzenetriol sulfate (2)'s total effect on sepsis progression. Conclusion : This study details the causal link between the plasma proteome and metabolome with sepsis, highlighting the roles of ICAM5 and 1,2,3-benzenetriol sulfate (2) in sepsis progression, both independently and through crosstalk.
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Objective: The Phoenix sepsis criteria define sepsis in children with suspected or confirmed infection who have ≥2 in the Phoenix Sepsis Score. The adoption of the Phoenix sepsis criteria eliminated the Systemic Inflammatory Response Syndrome criteria from the definition of pediatric sepsis. The objective of this study is to derive and validate machine learning models predicting in-hospital mortality for children with suspected or confirmed infection or who met the Phoenix sepsis criteria for sepsis and septic shock. ⋯ For children with Phoenix sepsis and Phoenix septic shock, the multivariable logistic regression, light gradient boosting machine, random forest, eXtreme Gradient Boosting, support vector machine, multilayer perceptron, and decision tree models predicting in-hospital mortality had AUPRCs of 0.48-0.65 (95% CI range: 0.42-0.66), 0.50-0.70 (95% CI range: 0.44-0.70), 0.52-0.70 (95% CI range: 0.47-0.71), 0.50-0.70 (95% CI range: 0.44-0.70), 0.49-0.67 (95% CI range: 0.43-0.68), 0.49-0.66 (95% CI range: 0.45-0.67), and 0.30-0.38 (95% CI range: 0.28-0.40) and AUROCs of 0.82-0.88 (95% CI range: 0.82-0.90), 0.84-0.88 (95% CI range: 0.84-0.90), 0.81-0.88 (95% CI range: 0.81-0.90), 0.84-0.88 (95% CI range: 0.83-0.90), 0.82-0.87 (95% CI range: 0.82-0.90), 0.80-0.86 (95% CI range: 0.79-0.89), and 0.76-0.82 (95% CI range: 0.75-0.85), respectively. Conclusion: Among children with Phoenix sepsis admitted to a PICU, the random forest model had the best AUPRC for in-hospital mortality compared to the light gradient boosting machine, eXtreme Gradient Boosting, logistic regression, multilayer perceptron, support vector machine, and decision tree models or a Phoenix Sepsis Score ≥ 2. These findings suggest that machine learning methods to predict in-hospital mortality in children with suspected infection predict mortality in a PICU setting with more accuracy than application of the Phoenix sepsis criteria.
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Background: Noncompressible torso hemorrhage remains a leading cause of potentially preventable deaths. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) has emerged as an adjunct temporizing hemorrhage control. The complete occlusion strategy with the ER-REBOA catheter can cause distal ischemia when used for longer than 30 min. ⋯ The partial aortic occlusion strategy was employed more often in the pREBOA-PRO group (87% vs. 33%, P < 0.05) and for longer periods (59 min vs. 50 min, P < 0.003). In contrast, AKI occurred less frequently in the pREBOA-PRO group (19% vs. 33%, P < 0.05). Conclusions: The more frequently partial and longer occlusion times in Zone 1 with the use of pREBOA-PRO resulted in lower AKI incidence suggesting that this newer device is a safer extended bridge to hemorrhage control.