American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2011
Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease.
There is increasing evidence for the presence of autoantibodies in chronic obstructive pulmonary disease (COPD). Chronic oxidative stress is an essential component in COPD pathogenesis and can lead to increased levels of highly reactive carbonyls in the lung, which could result in the formation of highly immunogenic carbonyl adducts on "self" proteins. ⋯ Carbonyl-modified proteins, arising as a result of oxidative stress, promote antibody production, providing a link by which oxidative stress could drive an autoimmune response in COPD.
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Am. J. Respir. Crit. Care Med. · Oct 2011
Editorial CommentThe importance of imaging in cystic fibrosis.