American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Nov 2011
Multicenter Study Comparative StudyThe progression of chronic obstructive pulmonary disease is heterogeneous: the experience of the BODE cohort.
Chronic obstructive pulmonary disease (COPD) is thought to result in rapid and progressive loss of lung function usually expressed as mean values for whole cohorts. ⋯ The progression of COPD is very heterogeneous. Most patients show no statistically significant decline of FEV(1) or increase in BODE. The multidimensional evaluation of COPD should offer insight into response to COPD management.
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Am. J. Respir. Crit. Care Med. · Nov 2011
Multicenter StudyObesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study.
Obesity has been linked to acute lung injury and is a risk factor for early mortality after lung transplantation. ⋯ Obesity is an independent risk factor for primary graft dysfunction after lung transplantation.
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Am. J. Respir. Crit. Care Med. · Nov 2011
Multicenter StudyEarly-onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis.
Although frequent, little is known about early-onset pneumonia that occurs in the postresuscitation period. Although induced hypothermia is recommended as a method of improving neurological outcome, its influence on the occurrence of early-onset pneumonia is not well defined. ⋯ After OHCA, therapeutic hypothermia is associated with an increased risk of early-onset pneumonia. This complication was associated with prolonged respiratory support and ICU stay, but did not significantly influence ICU mortality.
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Am. J. Respir. Crit. Care Med. · Nov 2011
Randomized Controlled TrialContinuous control of tracheal cuff pressure and microaspiration of gastric contents in critically ill patients.
Underinflation of the tracheal cuff frequently occurs in critically ill patients and represents a risk factor for microaspiration of contaminated oropharyngeal secretions and gastric contents that plays a major role in the pathogenesis of ventilator-associated pneumonia (VAP). ⋯ Continuous control of P(cuff) is associated with significantly decreased microaspiration of gastric contents in critically ill patients.