American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · May 2011
Treatment of tuberculosis with rifamycin-containing regimens in immune-deficient mice.
Daily rifapentine plus isoniazid-pyrazinamide in mice infected with Mycobacterium tuberculosis produces cure in 3 months. Whether cure corresponds to latent infection contained by host immunity or true tissue sterilization is unknown. ⋯ In nude mice, sterilization of tuberculosis is obtained with rifapentine-containing treatment, whereas failure with development of isoniazid resistance is obtained with rifampin-containing treatment.
-
Am. J. Respir. Crit. Care Med. · May 2011
Corticosteroid treatment in critically ill patients with pandemic influenza A/H1N1 2009 infection: analytic strategy using propensity scores.
Administration of adjuvant corticosteroids to patients with pandemic influenza A/H1N1 2009 (pH1N1) may reduce inflammation and improve outcomes. ⋯ Adjuvant corticosteroids were significantly associated with higher mortality in critically ill patients with pH1N1 infection.
-
Am. J. Respir. Crit. Care Med. · May 2011
Lung function and inflammatory responses in healthy young adults exposed to 0.06 ppm ozone for 6.6 hours.
Exposure to ozone causes a decrease in spirometric lung function and an increase in airway inflammation in healthy young adults at concentrations as low as 0.08 ppm, close to the National Ambient Air Quality Standard for ground level ozone. ⋯ Exposure of healthy young adults to 0.06 ppm ozone for 6.6 hours causes a significant decrement of FEV(1) and an increase in neutrophilic inflammation in the airways. GSTM1 genotype alone appears to have no significant role in modifying the effects.