American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2011
Corticosteroid treatment in critically ill patients with pandemic influenza A/H1N1 2009 infection: analytic strategy using propensity scores.
Administration of adjuvant corticosteroids to patients with pandemic influenza A/H1N1 2009 (pH1N1) may reduce inflammation and improve outcomes. ⋯ Adjuvant corticosteroids were significantly associated with higher mortality in critically ill patients with pH1N1 infection.
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Am. J. Respir. Crit. Care Med. · May 2011
Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A.
IL-22 has both proinflammatory and antiinflammatory properties. Its role in allergic lung inflammation has not been explored. ⋯ IL-22 is required for the onset of allergic asthma, but functions as a negative regulator of established allergic inflammation. Our study reveals that IL-22 contributes to the proinflammatory properties of IL-17A in experimental allergic asthma.