American journal of respiratory and critical care medicine
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Idiopathic pulmonary fibrosis (IPF) is a deadly progressive disease with few treatment options. Transglutaminase 2 (TG2) is a multifunctional protein, but its function in pulmonary fibrosis is unknown. ⋯ TG2 is involved in pulmonary fibrosis in a mouse model and in human disease and is important in normal fibroblast function. With continued research on TG2, it may offer a new therapeutic target.
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Am. J. Respir. Crit. Care Med. · Sep 2011
Short-course chemotherapy with TMC207 and rifapentine in a murine model of latent tuberculosis infection.
Multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) is an emerging global health threat. Proper management of close contacts of infectious patients is increasingly important. However, no evidence-based recommendations for treating latent TB infection (LTBI) after MDR/XDR-TB exposure (DR-LTBI) exist. An ultrashort regimen for LTBI caused by drug-susceptible strains (DS-LTBI) is also desirable. TMC207 has bactericidal and sterilizing activity in animal models of TB and improves the activity of current MDR-TB therapy in patients. ⋯ TMC207 has substantial sterilizing activity and may enable treatment of DR-LTBI in 3-4 months.
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Am. J. Respir. Crit. Care Med. · Sep 2011
Letter Case ReportsRight pulmonary agenesis in a 12-year-old girl.