American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Nov 2012
Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapy.
Ongoing efforts to improve pulmonary gene transfer thereby enabling gene therapy for the treatment of lung diseases, such as cystic fibrosis (CF), has led to the assessment of a lentiviral vector (simian immunodeficiency virus [SIV]) pseudotyped with the Sendai virus envelope proteins F and HN. ⋯ The data support F/HN-pseudotyped SIV as a promising vector for pulmonary gene therapy for several diseases including CF. We are now undertaking the necessary refinements to progress this vector into clinical trials.