American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Nov 2012
Adenosine A(2B) receptor deficiency promotes host defenses against gram-negative bacterial pneumonia.
Activation of the adenosine A(2B) receptor (A(2B)R) promotes antiinflammatory effects in diverse biological settings, but the role of this receptor in antimicrobial host defense in the lung has not been established. Gram-negative bacillary pneumonia is a common and serious illness associated with high morbidity and mortality, the treatment of which is complicated by increasing rates of antibiotic resistance. ⋯ These data suggest that the absence of A(2B)R signaling enhances antimicrobial activity in gram-negative bacterial pneumonia.