American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2012
ReviewThe next generation of complex lung genetic studies.
Common genetic risk variants identified by genome-wide association studies have explained a small portion of disease heritability in complex diseases. It is becoming apparent that each gene/locus is heterogeneous and that multiple rare independent risk alleles across the population contribute to disease risk. ⋯ Although data analysis approaches are still evolving, a number of published studies have successfully identified rare variants associated with complex disease. Despite many challenges that lie ahead in applying these technologies to lung disease, rare variants are likely to be a critical piece of the puzzle that needs to be solved to understand the genetic basis of complex lung disease and to use this information to develop better therapies.
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Am. J. Respir. Crit. Care Med. · Dec 2012
Letter Randomized Controlled Trial Comparative StudyPlasma gelsolin levels in the diagnosis, prognosis, and treatment of lung complications of prematurity.
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Am. J. Respir. Crit. Care Med. · Dec 2012
Comparative StudyRhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease.
Chronic obstructive pulmonary disease (COPD) exacerbations are associated with virus (mostly rhinovirus) and bacterial infections, but it is not known whether rhinovirus infections precipitate secondary bacterial infections. ⋯ Rhinovirus infections are frequently followed by secondary bacterial infections in COPD and cleavage of the antimicrobial peptides SLPI and elafin by virus-induced neutrophil elastase may precipitate these secondary bacterial infections. Therapy targeting neutrophil elastase or enhancing innate immunity may be useful novel therapies for prevention of secondary bacterial infections in virus-induced COPD exacerbations.
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Am. J. Respir. Crit. Care Med. · Dec 2012
Letter Review Case ReportsA case of cranial air embolism after transthoracic lung biopsy.