American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Feb 2012
Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension.
This perspective highlights advances in the understanding of the role of cellular metabolism in the pathogenesis of pulmonary hypertension. Insights gained in the past 20 years have revealed several similarities between the cellular processes underlying the pulmonary vascular remodeling in pulmonary hypertension and those seen in cancer processes. ⋯ The glycolytic shift may underlie the resistance to apoptosis and increased vascular cell proliferation, which are hallmarks of pulmonary hypertension. These investigations have led to novel approaches in the diagnosis and therapy of pulmonary hypertension.
-
Am. J. Respir. Crit. Care Med. · Feb 2012
Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension.
Patients with idiopathic pulmonary arterial hypertension (IPAH) present circulating autoantibodies against vascular wall components. Pathogenic antibodies may be generated in tertiary (ectopic) lymphoid tissues (tLTs). ⋯ We highlight the main features of lymphoid neogenesis specifically in the lungs of patients with IPAH, providing new evidence of immunological mechanisms in this severe condition.