American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Mar 2012
A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinoviruses.
Human rhinoviruses (HRV) are the leading cause of upper respiratory infections and have been postulated to trigger asthma exacerbations. However, whether HRV are detected during crises because upper respiratory infections often accompany asthma attacks, or because they specifically elicit exacerbations, is unclear. Moreover, although several hypotheses have been advanced to explain virus-induced exacerbations, their mechanism remains unclear. ⋯ Our findings suggest that HRV infections in children with asthma are specifically associated with acute wheezing, and that type III IFN-λ(1) responses mediate exacerbations caused by HRV. Modulation of IFN- λ(1) should be studied as a therapeutic target for exacerbations caused by HRV.
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Am. J. Respir. Crit. Care Med. · Mar 2012
Platelet activation, P-selectin, and eosinophil β1-integrin activation in asthma.
Eosinophil β1-integrin activation correlates inversely with FEV1 and directly with eosinophil-bound P-selectin in subjects with nonsevere allergic asthma. ⋯ The relationship between eosinophil β1-integrin activation and pulmonary function was replicated only for younger subjects with nonsevere asthma. However, we infer that platelet activation and binding of activated platelets to eosinophils followed by P-selectin-mediated eosinophil β1-integrin activation occur in both nonsevere and severe asthma with rapid movement of platelet-eosinophil complexes into the lung in more severe disease.
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Am. J. Respir. Crit. Care Med. · Mar 2012
Letter Case ReportsEndobronchial metastasis from gastrinoma of the pancreas.