American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Apr 2012
Comparative StudyA critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting.
Acute lung injury (ALI) is a debilitating condition associated with severe skeletal muscle weakness that persists in humans long after lung injury has resolved. The molecular mechanisms underlying this condition are unknown. ⋯ These data show that MuRF1 is responsible for mediating muscle atrophy that occurs during the period of active lung injury in ALI mice and that, as in humans, skeletal muscle dysfunction persists despite resolution of lung injury.
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Am. J. Respir. Crit. Care Med. · Apr 2012
Comparative StudyEarly cystic fibrosis lung disease detected by bronchoalveolar lavage and lung clearance index.
Unrecognized airway infection and inflammation in young children with cystic fibrosis (CF) may lead to irreversible lung disease; therefore early detection and treatment is highly desirable. ⋯ The LCI is elevated early in CF, especially in the presence of Pseudomonas and airway inflammation. The LCI is a feasible, repeatable, and sensitive noninvasive marker of lung disease in young children with CF.
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Am. J. Respir. Crit. Care Med. · Apr 2012
Editorial CommentDoes the hospital make you older faster?
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Am. J. Respir. Crit. Care Med. · Apr 2012
Comparative StudySpurious inferences about long-term outcomes: the case of severe sepsis and geriatric conditions.
Survivors of critical illness suffer significant limitations and disabilities. ⋯ Geriatric conditions are common after severe sepsis. However, severe sepsis is associated with increased rates of only a subset of geriatric conditions, not all. In studying outcomes after acute illness, failing to measure and control for both preillness levels and trajectories may result in erroneous conclusions.