American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Oct 2013
Systemic sRAGE is a Biomarker of Emphysema and Associated with AGER Genetic Variants in COPD Patients.
Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because of concerns regarding radiation exposure and cost. ⋯ Lower circulating sRAGE levels are associated with emphysema severity and genetic polymorphisms in the AGER locus are associated with systemic sRAGE levels. Clinical trial registered with www.clinicaltrials.gov (NCT 00413205 and NCT 00292552).