American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Oct 2013
Arsenic Exposure and Impaired Lung Function. Findings from a Large Population-based Prospective Cohort Study.
Exposure to arsenic through drinking water has been linked to respiratory symptoms, obstructive lung diseases, and mortality from respiratory diseases. Limited evidence for the deleterious effects on lung function exists among individuals exposed to a high dose of arsenic. ⋯ This large population-based study confirms that arsenic exposure is associated with impaired lung function and the deleterious effect is evident at low- to moderate-dose range.
-
Am. J. Respir. Crit. Care Med. · Oct 2013
Relative Respiratory Syncytial Virus Cytopathogenesis in Upper and Lower Respiratory Tract Epithelium.
Respiratory syncytial virus (RSV) is a major pathogen that primarily infects airway epithelium. Most infants suffer mild upper respiratory tract (URT) symptoms, whereas approximately one-third progress to lower respiratory tract (LRT) involvement. Despite the ubiquity of URT infection, little is known about the relative cytopathogenesis of RSV infection in infant URT and LRT. ⋯ RSV induced remarkably similar, albeit quantitatively lower, cytopathogenesis and proinflammatory responses in WD-PNECs compared with WD-PBECs that reproduce many hallmarks of RSV pathogenesis in infants. WD-PNECs may provide an authentic surrogate model with which to study RSV cytopathogenesis in infant airway epithelium.
-
Am. J. Respir. Crit. Care Med. · Oct 2013
Chronic Obstructive Pulmonary Disease and Cerebral Microbleeds. The Rotterdam Study.
Chronic obstructive pulmonary disease (COPD) is a common, complex multisystem disease in the elderly with multiple comorbidities that significantly impact morbidity and mortality. Although cerebral small-vessel disease is an important cause of cognitive decline and age-related disability, it is a poorly investigated potential systemic manifestation of patients with COPD. ⋯ Our findings are compatible with COPD causing an increased risk of the development of cerebral microbleeds in deep or infratentorial locations.