American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Dec 2013
Hypoxia Promotes Danger-Mediated Inflammation via RAGE in Cystic Fibrosis.
Hypoxia regulates the inflammatory-antiinflammatory balance by the receptor for advanced glycation end products (RAGE), a versatile sensor of damage-associated molecular patterns. The multiligand nature of RAGE places this receptor in the midst of chronic inflammatory diseases. ⋯ A causal link between hyperactivation of RAGE and inflammation in CF has been observed, such that targeting pathogenic inflammation alleviated inflammation in CF and measurement of sRAGE levels could be a useful biomarker for RAGE-dependent inflammation in patients with CF.