American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jan 2013
ReviewNeurohormonal axis in patients with pulmonary arterial hypertension: friend or foe?
Despite its description some 25 years ago, neurohormonal activation has long been neglected as an important factor in the pathophysiology of pulmonary arterial hypertension (PAH). Neurohormonal activation was interpreted as a necessary compensatory response to maintain cardiac contractility and systemic blood pressure. ⋯ However, recent data revealed that sympathetic overstimulation is strongly related to mortality, and blockade of neurohormonal activity in experimental PAH improved survival and cardiac function. These novel insights shed new light on the role of neurohormonal activity in PAH.
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Am. J. Respir. Crit. Care Med. · Jan 2013
Multicenter StudyAssociation between obstructive sleep apnea and cancer incidence in a large multicenter Spanish cohort.
Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also associated with cancer incidence is unknown. ⋯ Increased overnight hypoxia as a surrogate of OSA severity was associated with increased cancer incidence. This association seems to be limited to men and patients younger than 65 years of age.