American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2013
Regulation and function of epithelial secreted phospholipase A2 group X in asthma.
Indirect airway hyperresponsiveness (AHR) is a fundamental feature of asthma that is manifest as exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 group X (sPLA2-X) plays a key role in regulating eicosanoid formation and the development of inflammation and AHR in murine models. ⋯ These data reveal a relationship between epithelial-derived sPLA2-X and indirect AHR in asthma and that sPLA2-X serves as an epithelial regulator of inflammatory eicosanoid formation. Therapies targeting epithelial sPLA2-X may be useful in asthma.
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Am. J. Respir. Crit. Care Med. · Jul 2013
Letter Randomized Controlled TrialEffects of decontamination of the digestive tract and oropharynx in intensive care unit patients on 1-year survival.
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Am. J. Respir. Crit. Care Med. · Jul 2013
Pseudomonas aeruginosa ventilator-associated pneumonia. predictive factors of treatment failure.
The predictive factors of treatment failure for ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa (PA) remain uncertain. ⋯ Neither resistance profile nor biantibiotic therapy decreased the risk of PA-VAP treatment failure. However, the profile of PA resistance prolonged the length of stay. Better evaluation of the potential benefit of an initial treatment containing FQ requires further randomized trials.