American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Jul 2013
Comparative StudyComparison of 2011 and 2007 Global Initiative for Chronic Obstructive Lung Disease guidelines for predicting mortality and hospitalization.
The GOLD (Global Initiative for Chronic Obstructive Lung Disease) 2011 update on chronic obstructive pulmonary disease (COPD) bases disease classification on level of dyspnea, exacerbation history, and FEV1, whereas the previous GOLD categorized disease severity according to FEV1 only. Information on how the new classification predicts long-term hospitalizations and mortality is limited. ⋯ The predictive ability of GOLD 2011 did not differ significantly from GOLD 2007 in terms of hospitalizations and mortality.
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Am. J. Respir. Crit. Care Med. · Jul 2013
Regulation and function of epithelial secreted phospholipase A2 group X in asthma.
Indirect airway hyperresponsiveness (AHR) is a fundamental feature of asthma that is manifest as exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 group X (sPLA2-X) plays a key role in regulating eicosanoid formation and the development of inflammation and AHR in murine models. ⋯ These data reveal a relationship between epithelial-derived sPLA2-X and indirect AHR in asthma and that sPLA2-X serves as an epithelial regulator of inflammatory eicosanoid formation. Therapies targeting epithelial sPLA2-X may be useful in asthma.
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Am. J. Respir. Crit. Care Med. · Jul 2013
Letter Randomized Controlled TrialEffects of decontamination of the digestive tract and oropharynx in intensive care unit patients on 1-year survival.
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Am. J. Respir. Crit. Care Med. · Jul 2013
Pseudomonas aeruginosa ventilator-associated pneumonia. predictive factors of treatment failure.
The predictive factors of treatment failure for ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa (PA) remain uncertain. ⋯ Neither resistance profile nor biantibiotic therapy decreased the risk of PA-VAP treatment failure. However, the profile of PA resistance prolonged the length of stay. Better evaluation of the potential benefit of an initial treatment containing FQ requires further randomized trials.