American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Dec 2014
Practice GuidelineAn Official American Thoracic Society Clinical Practice Guideline: The Diagnosis of Intensive Care Unit-acquired Weakness in Adults.
Profound muscle weakness during and after critical illness is termed intensive care unit-acquired weakness (ICUAW). ⋯ Research that identifies treatments that benefit patients with ICUAW is necessary to determine whether the benefits of diagnostic testing for ICUAW outweigh its burdens.
-
Am. J. Respir. Crit. Care Med. · Dec 2014
Circulating Fibrocytes as Biomarker of Prognosis in Hermansky-Pudlak Syndrome.
The rate of progression of most interstitial lung diseases (ILD) is unpredictable. Fibrocytes are circulating bone marrow-derived cells that have been implicated in the pathogenesis of lung fibrosis. Hermansky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers of ILD in a homogeneous population at near-certain risk of developing fibrotic lung disease. ⋯ CXCR4(+) fibrocyte concentration may be useful as a biomarker for outcome of ILD in subjects with HPS.