American journal of respiratory and critical care medicine
-
Am. J. Respir. Crit. Care Med. · Dec 2014
Comparative StudyPatient-Centric Blood Pressure Targeted CPR Improves Survival from Cardiac Arrest.
Although current resuscitation guidelines are rescuer focused, the opportunity exists to develop patient-centered resuscitation strategies that optimize the hemodynamic response of the individual in the hopes to improve survival. ⋯ Blood pressure-targeted CPR improves 24-hour survival compared with optimal American Heart Association care in a porcine model of asphyxia-associated VF cardiac arrest.
-
Am. J. Respir. Crit. Care Med. · Dec 2014
Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis (IPF).
Idiopathic pulmonary fibrosis (IPF) is an untreatable and often fatal lung disease that is increasing in prevalence and is caused by complex interactions between genetic and environmental factors. Epigenetic mechanisms control gene expression and are likely to regulate the IPF transcriptome. ⋯ These results suggest that DNA methylation may be involved in the pathogenesis of IPF.
-
Am. J. Respir. Crit. Care Med. · Dec 2014
Sustained Effects of Sirolimus on Lung Function and Cystic Lung Lesions in Lymphangioleiomyomatosis.
Sirolimus therapy stabilizes lung function and reduces the size of chylous effusions and lymphangioleiomyomas in patients with lymphangioleiomyomatosis. ⋯ Sirolimus therapy slowed down lung function decline and increase in cystic lesions. Most patients were able to tolerate sirolimus therapy.
-
Am. J. Respir. Crit. Care Med. · Dec 2014
Clinical Predictors of the Respiratory Arousal Threshold in Patients with Obstructive Sleep Apnea.
A low respiratory arousal threshold (ArTH) is one of several traits involved in obstructive sleep apnea pathogenesis and may be a therapeutic target; however, there is no simple way to identify patients without invasive measurements. ⋯ Our results demonstrate that individuals with a low ArTH can be identified from standard, clinically available variables. This finding could facilitate larger interventional studies targeting the ArTH.