American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2014
Genome-wide Study of Percent Emphysema on CT in the General Population: The MESA Lung/SHARe Study.
Pulmonary emphysema overlaps partially with spirometrically defined chronic obstructive pulmonary disease and is heritable, with moderately high familial clustering. ⋯ Our results suggest that some genes previously identified as influencing lung function are independently associated with emphysema rather than lung function, and that genes related to α-mannosidase may influence risk of emphysema.
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Am. J. Respir. Crit. Care Med. · Feb 2014
Glutaredoxin-1 Attenuates S-glutathionylation of the Death Receptor Fas and Decreases Resolution of Pseudomonas aeruginosa Pneumonia.
The death receptor Fas is critical for bacterial clearance and survival of mice after Pseudomonas aeruginosa infection. ⋯ These results suggest that S-glutathionylation of Fas within the lung epithelium enhances epithelial apoptosis and promotes clearance of P. aeruginosa and that glutaredoxin-1 impairs bacterial clearance and increases the severity of pneumonia in association with deglutathionylation of Fas.
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Am. J. Respir. Crit. Care Med. · Feb 2014
Deficiency of MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation.
Respiratory viral infections can result in the establishment of chronic lung diseases. Understanding the early innate immune mechanisms that participate in the development of chronic postviral lung disease may reveal new targets for therapeutic intervention. The intracellular viral sensor protein melanoma differentiation-associated protein 5 (MDA5) sustains the acute immune response to Sendai virus, a mouse pathogen that causes chronic lung inflammation, but its role in the development of postviral chronic lung disease is unknown. ⋯ MDA5 modulates the development of chronic lung inflammation by regulating the early inflammatory response in the lung.