American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Feb 2014
Spirometry and Health Status Worsen with Weight Gain in Obese but Improve in Normal-weight Smokers.
The literature on the effect of obesity and weight gain on respiratory outcomes in smokers is contradictory. ⋯ Weight gain affects respiratory outcomes differently between obese and normal-weight smokers. Whereas FEV1 and health status decrease with weight gain among obese smokers, they improve among normal-weight smokers. The nonlinear relationship between weight gain and respiratory outcomes suggests that this effect of excess weight is unlikely to be mechanical alone.
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Am. J. Respir. Crit. Care Med. · Feb 2014
Simultaneous Targeting of Interleukin-1 and -18 is Required for Protection against Inflammatory and Septic Shock.
Sepsis is one of the leading causes of death around the world. The failure of clinical trials to treat sepsis demonstrates that the molecular mechanisms are multiple and are still insufficiently understood. ⋯ Our data point toward the therapeutic potential of neutralizing IL-1 and IL-18 simultaneously in sepsis, rather than inhibiting the upstream inflammatory caspases.