American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Apr 2014
Multicenter Study Comparative StudyElectronic implementation of a novel surveillance paradigm for ventilator-associated events: feasibility and validation.
Accurate surveillance of ventilator-associated pneumonia (VAP) is hampered by subjective diagnostic criteria. A novel surveillance paradigm for ventilator-associated events (VAEs) was introduced. ⋯ Concordance between the novel VAE algorithm and VAP was poor. Incidence and associated mortality of VAE were susceptible to small differences in electronic implementation. More studies are needed to characterize the clinical entities underlying VAE and to ensure comparability of rates from different institutions.
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Am. J. Respir. Crit. Care Med. · Apr 2014
GuidelineOfficial american thoracic society technical standards: spirometry in the occupational setting.
This document addresses aspects of the performance and interpretation of spirometry that are particularly important in the workplace, where inhalation exposures can affect lung function and cause or exacerbate lung diseases, such as asthma, chronic obstructive pulmonary disease, or fibrosis. ⋯ Important aspects of workplace spirometry are discussed and recommendations are provided for the performance and interpretation of workplace spirometry.
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Am. J. Respir. Crit. Care Med. · Apr 2014
Comparative StudyCCL17 Production by Dendritic Cells is Required for NOD1-mediated Exacerbation of Allergic Asthma.
Pattern recognition receptors are attractive targets for vaccine adjuvants, and polymorphisms of the innate receptor NOD1 have been associated with allergic asthma. ⋯ Data from this study unveil a deleterious role of NOD1 in allergic asthma through direct induction of CCL17 by dendritic cells, arguing for a need to address vaccine formulation safety issues related to allergy.