American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · May 2014
Editorial CommentActive lifestyle: the next "smoking cessation"?
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Am. J. Respir. Crit. Care Med. · May 2014
Randomized Controlled Trial Multicenter StudyRisk Factors for Physical Impairment after Acute Lung Injury in a National, Multi-Center Study.
Existing studies of risk factors for physical impairments in acute lung injury (ALI) survivors were potentially limited by single-center design or relatively small sample size. ⋯ Patients had substantial impairments, from predicted values, for 6-minute-walk distance and SF-36 Physical Function outcome measures. Minimizing corticosteroid dose and implementing existing evidence-based methods to reduce duration of intensive care unit stay and associated patient immobilization may be important interventions for improving ALI survivors' physical outcomes.
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Am. J. Respir. Crit. Care Med. · May 2014
Multicenter Study Clinical TrialLow titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A(H1N1) 2009 infection.
The biology of fatal pandemic influenza infection remains undefined. ⋯ Early negative A(H1N1) 2009 HI serology can predict death from influenza. This negative serology in fatal cases in young adults reflects the trapping of anti-H1N1 antibodies in immune complexes in the lungs, associated with poor specific helper T-cell response. Clinical trial registered with www.clinicaltrials.gov (NCT 01089400).
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Am. J. Respir. Crit. Care Med. · May 2014
Multicenter Study Observational StudyAssociation between source of infection and hospital mortality in patients who have septic shock.
Mortality caused by septic shock may be determined by a systemic inflammatory response, independent of the inciting infection, but it may also be influenced by the anatomic source of infection. ⋯ Anatomic source of infection should be considered in future trial designs and analyses, and in development of prognostic scoring systems.