American journal of respiratory and critical care medicine
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Am. J. Respir. Crit. Care Med. · Aug 2014
Integrative 'Omic Analysis of Experimental Bacteremia Identifies a Metabolic Signature that Distinguishes Human Sepsis from SIRS.
Sepsis is a leading cause of morbidity and mortality. Currently, early diagnosis and the progression of the disease are difficult to make. The integration of metabolomic and transcriptomic data in a primate model of sepsis may provide a novel molecular signature of clinical sepsis. ⋯ A model of sepsis based on reciprocal metabolomic and transcriptomic data was developed in primates and validated in two human patient cohorts. It is anticipated that the identified parameters will facilitate early diagnosis and management of sepsis.
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Am. J. Respir. Crit. Care Med. · Aug 2014
Gender-dependent Influence of Endogenous Estrogen in Pulmonary Hypertension.
The incidence of pulmonary arterial hypertension is greater in women, suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males, exogenously administered estrogen can protect against pulmonary hypertension (PH). However, in models that display female susceptibility, estrogens may play a causative role. ⋯ The unique phenotype of female pulmonary arteries facilitates the therapeutic effects of anastrozole in experimental PH confirming a role for endogenous estrogen in the disease pathogenesis in females and suggests aromatase inhibitors may have therapeutic potential.